Will this hose work with my turbo or supercharger setup?

Yes. 3-ply silicone handles boost environments and thermal cycling without degrading. Confirm your intake manifold uses a 2.50" connection point before ordering.

Do I need clamps, or are they included?

Hose only — you'll need to source clamps separately. Standard T-bolt or worm-drive clamps fit the 2.50" diameter.

Can I run this hose near the engine block, or will heat break it down?

Silicone handles sustained heat well. Route it away from direct contact with exhaust components and sharp edges. Allow air gap between the hose and hot surfaces whenever possible.