Will this hose work for both coolant and boost applications?

Yes. Three-ply silicone handles coolant temps and turbo boost pressure. If you're running it on a high-heat turbo outlet, confirm your clamp style won't slip under sustained heat cycles.

Do I need to use spring clamps or worm clamps with this?

Either works. Spring clamps are faster to install; worm clamps give you more adjustment if the hose needs to settle. No clamps are included, so you'll need to source them separately based on your hose barb size.

Can I use this hose if my ports don't line up at 90 degrees exactly?

The elbow is fixed at 90 degrees, so your inlet and outlet ports need to match that angle. If your routing requires a different bend, you may need a universal flex hose or multiple 45-degree pieces instead.